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Year : 2015  |  Volume : 3  |  Issue : 1  |  Page : 33

Multiple myeloma presenting as pleural mass

Department of General Medicine, Muslim Educational Society Medical College, Perinthalmanna, Kerala, India

Date of Web Publication12-Dec-2014

Correspondence Address:
Mansoor C Abdulla
Department of General Medicine, M. E. S. Medical College, Perinthalmanna - 679 338, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2320-8775.146854

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How to cite this article:
Abdulla MC, Alungal J. Multiple myeloma presenting as pleural mass . J Assoc Chest Physicians 2015;3:33

How to cite this URL:
Abdulla MC, Alungal J. Multiple myeloma presenting as pleural mass . J Assoc Chest Physicians [serial online] 2015 [cited 2022 Jun 25];3:33. Available from: https://www.jacpjournal.org/text.asp?2015/3/1/33/146854

A 61-year-old male presented with hemoptysis, low back pain, and significant weight loss for 2 months. He had never experienced any previous medical problems. He was fully conscious and oriented, emaciated, had grade two clubbing. His vitals were stable, and had dullness and reduced breath sounds over right supraclavicular and infraclavicular areas. He had normocytic normochromic anemia, very high erythrocyte sedimentation rate (ESR), and mild renal impairment. An upright posteroanterior (PA) view of chest radiograph showed homogenous opacity of right upper zone, clavicular fracture on right side, and bony erosions [Figure 1]a, and computed tomographic scan with contrast of the chest showed 4.0 × 1.7 cm contrast-enhancing soft tissue density peripherally in posterior pleural surface in right upper lobe apicoposterior region and heterogeneous bone densities in the ribs and vertebral bodies [Figure 1]b-d.
Figure 1: Chest radiograph showing homogenous opacity of right upper zone (a) and CT Thorax showing 4.0 × 1.7 cms contrast enhancing soft tissue density peripherally in posterior pleural surface in right upprer lobe (b-d)

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Our patient was diagnosed to have multiple myeloma (bone marrow aspiration showing 48% plasma cells, M band on serum protein electrophoresis, and lytic lesions on X-ray skull and vertebra) with extramedullary dissemination to pleura presenting as pleural mass on biopsy. Extraosseous myelomarefers to a rare manifestation of multiple myeloma where there is plasma cell proliferation outside the skeletal and their presence has been associated with more aggressive disease. [1] Extramedullary involvement in multiple myeloma usually involves the nasopharynx, upper respiratory tract, or gastrointestinal tract. [2] Pleuropulmonary disease is more unusual and includes pulmonary infiltrates, parenchymal masses, airway lesions, and pleural effusions. [3] Pleural mass lesions in myeloma are very rare and few cases have been described previously.

  References Top

Moulopoulos LA, Granfield CA, Dimopoulos MA, Kim EE, Alexanian R, Libshitz HI. Extraosseous multiple myeloma: Imaging features. AJR Am J Roentgenol 1993;161:1083-7.  Back to cited text no. 1
Cabrera A, Klein JS. Bilateral pleural masses and shortness of breath associated with multiple myeloma. Chest 1997;111:1750-3.  Back to cited text no. 2
Kravis MM, Hutton LC. Solitary plasma cell tumor of the pleura manifested as massive hemothorax. AJR Am J Roentgenol 1993;161:543-4.  Back to cited text no. 3


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