|LETTER TO EDITOR
|Year : 2019 | Volume
| Issue : 2 | Page : 78
Primary pulmonary synovial sarcoma: is it worth all the hard work?
Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
|Date of Web Publication||20-Jun-2019|
Prof. Mahmood Dhahir Al-Mendalawi
Professor in Paediatrics and Child Health, Consultant Pediatrician, Department of Paediatrics, Al-
Kindy College of Medicine, University of Baghdad
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Al-Mendalawi MD. Primary pulmonary synovial sarcoma: is it worth all the hard work?. J Assoc Chest Physicians 2019;7:78
I have read with interest the case report by Singhal et al. published in January–June 2019 issue of the Journal of Association of Chest Physicians. The authors described the escalating clinical presentation, diagnostic work-up, and the treatment plan instituted to an Indian patient with primary pulmonary synovial sarcoma (PPSS). In the light of the rarity of that aggressive and malignant neoplasm, I presume that the defective immunity ought to be seriously considered in the studied patient. Among conditions closely linked to defective immune status, human immunodeficiency virus (HIV) infection has the great priority. It is known that due to impaired immunity, HIV-infected patients are prone to various neoplastic disorders more than patients with competent immune system. Among these neoplasms, PPSS has been reported in HIV-positive patients. In India, HIV infection is a substantial health problem. The available data pointed out to the national HIV seroprevalence of 0.26% compared with a global average of 0.2%. Implementing the diagnostic battery of CD4 lymphocyte count and viral overload, measurements would have to be envisaged in the studied patient. If that battery was to disclose underlying HIV infection, the case in question could be surely regarded the second novel case report of HIV-associated PPSS in India. The first case was reported 9 years earlier.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Singhal S, Prajapat DK, Sharma RK, Talwar D. Primary pulmonary synovial sarcoma: is it worth all the hard work? J Assoc Chest Phys 2019;7:29-34.
Ji Y, Lu H. Malignancies in HIV-infected and AIDS patients. Adv Exp Med Biol 2017;1018:167-79.
Shah UB, Joshi S, Ghorpade SV, Gaikwad SN, Sundrani RM. Primary pleuro-pulmonary synovial sarcoma. Indian J Chest Dis Allied Sci 2010;52:169-72.
Paranjape RS, Challacombe SJ. HIV/AIDS in India: an overview of the Indian epidemic. Oral Dis 2016; 22(Suppl 1):10-4.